A persistent feeling of despondency and desolation is a sure sign that the person is suffering from depression. In a state of depression it becomes quite challenging to work, study, sleep, eat, and enjoy any activities with friends or even individually. Some people have depression only once in their life, while others have it several times in a lifetime. Major depression seems to occur from one generation to the next in some families but may affect people with no family history of the illness. Older adults suffer depression more frequently and acutely than younger adults. Older adults also have a greater chance of relapse than younger adults.

Besides, depression in the elderly is commonly linked to cognitive impairment and heart diseases. Besides, age-related biological and psychological factors may underlie a different phenomenology of late-life and early-life depression. For treating older adults for the first time for depressions clinicians were advised to refrain from diagnosing major depression in individuals within the first two months following the death of a loved one in what has been referred to as the “bereaved. Bereavement exclusion suggested that grief somehow protected someone from major depression. Some anxiety may be good for depressed people, because anxiety coupled with worrying may help relieve depression.

Researchers used functional Magnetic Resonance Imaging (MRI) to look at brain activity in subjects who were depressed and not anxious, anxious but not depressed, or who exhibited varying degrees of depression and one or both types of anxiety. Depression is less common among older adults than younger adults but can have serious consequences because depressed older adults are less likely to endorse affective symptoms and more likely to display cognitive changes, somatic symptoms, and loss of interest than are younger adults. Medication use in older adults is often inappropriate and erroneous, partly because of the complexities of prescribing and partly because of many patients, provider, and health system factors that substantially influence the therapeutic value of medications in aged people.

Older people have substantial internal individual variability in health, disability, age-related changes, poly-morbidity, and associated poly-pharmacy, making a generalization of prescribing recommendations difficult. Personality disorders are mental disorders that generate maladaptive behavior based on a person’s environment and inner experiences which are different from the expected norms of behavior. On the other hand, eccentricity means quirkiness which refers to unusual or odd behavior by an individual. This behavior would typically be perceived as unusual or unnecessary, without being classified as a mental disorder. Eccentricity is the opposite of ‘normal’ “behavior, the common means by which individuals in society solve given problems and pursue certain priorities in everyday life.